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53 9 9 3. INDEX EBNA-1 protein, 172, 298 EC Council Directives, 329, 340, 342 EC guidelines, 329 Epstein-Barr virus (EBV), 172 Equine infectious anaemia virus (EIAV), 61, 82 Erythropoietin (Epo) gene, 2334 European Medicines Evaluation Agency (EMEA), 327, 329, 347, 355, 357 Factor VIII, B-domain-deleted, 196, 197 gene, 196 protein, 1967, 202, 203 secreting fibroblasts, 199200 synthesis, 196, 198 Factor IX, gene, 196, 201 protein, 196, 201, 202 synthesis, 201 Feline immunodeficiency virus FIV), 61 Food and Drug Administration (FDA) of USA, 342, 348, 3601 5-fluorouracil, 127 Ganciclovir, 92, 97, 127, 303 Gene Therapy Advisory Committee (GTAC) of UK, 330, 360 Genetically-modified cells, 323, 325, 337, 343 Genetically-modified organisms (GMOs), 329, 347, 3501, 352 EC directives, 385 GenTG (Germany), 3501 German Central Commission for Biological safety, 351 German Drug Law, 347 German Gene Technology Law, 347 German Gene Therapy Register, 355 German Medical Association, 353, 355 German Transplantation Law, 349 German Working Group for Gene therapy, 355, 356 Gibbon ape leukaemia virus (GaLV), 39 -globin, 2345 antisense RNA, 232 -globin, 227, 233, 234 homologous recombination, 232 s-globin, 236 -globin, 227, 2312, 233, 234 Good Laboratory Practice (GLP), 3623, 405 37581 documentation, 3789 responsibility, 377 role of quality assurance, 3801 role of study director, 37980 traceability, 3778 Good Manufacturing Practice (GMP), 328, 334, 337, 353, 362, 364, 365, 375, 38399 manufacturing conditions and strategies, 38399 bacterial fermentation, 394 building design, 3989 cell culture options, 3912 Certificates of Analysis (C of As) 378, 386 clean-rooms, 3879 documentation, 3968 equipment, 395, 396 guidelines, 3845 host cell banks, 392 master validation plan, 3956, 397 plasmid downstream processing, 394 practical considerations, 3857 quality assurance (QA), 384, 385, 387 quality control(QC), 384 viral downstream processing, 393 virus banks, 392 virus storage, 3934 Haemoglobin, 227 foetal, 232, 233, 235, 236 Haemoglobin Usa trading, 227 polymerisation, 236 Haemoglobinopathies, 22737 globin gene therapy, 229 globin retroviral vector, 22931 Haemophilia, 195203 haemophilia A, implantation of retrovirally-transduced cells, 199200 in vivo gene therapy, 200 haemophilia B, in vivo gene therapy, 201 Haemophiliac dogs, 200, 201 Hairpin ribozyme, 300, 302 Hammerhead ribozyme, 3001 mostly tan with a thick, dark brown or black brush at the tip.

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